Patients with predominantly
non-upper lobe emphysema and a high maximal workload.
4.3.2.3 Patients should have none of
the following exclusion criteria:
4.3.2.3.1 Previous LVRS.
4.3.2.3.2 Pleural or interstitial disease
which precludes surgery.
4.3.2.3.3 Giant bulla (greater than one-third
the volume of the lung in which the bulla is located).
4.3.2.3.4 Clinically significant bronchiectasis.
4.3.2.3.5 Pulmonary nodule requiring
surgery.
4.3.2.3.6 Previous lobectomy.
4.3.2.3.7 Uncontrolled hypertension (systolic
greater than 200 mm Hg or diastolic greater than 100 mm Hg).
4.3.2.3.8 Oxygen requirement greater
than 6 liters per minute during resting to keep oxygen saturation
greater than or equal to 90%.
4.3.2.3.9 History of recurrent infections
with clinically significant production of sputum.
4.3.2.3.10 Unplanned weight loss greater
than 10% within three months prior to consideration for surgery.
4.3.2.3.11 Pulmonary hypertension, defined
as mean pulmonary artery pressure of 33 mm Hg or greater on right-heart
catheterization or peak systolic pulmonary artery pressure of 44
mm Hg or greater.
4.3.2.3.12 Resting bradycardia (less than
50 beats per minute), frequent multifocal Premature Ventricular
Contractions (PVCs) of complex ventricular arrhythmia or sustained
Supraventricular Tachycardia (SVT).
4.3.2.3.13 Evidence of systemic disease
or neoplasia that is expected to compromise survival.